-- Detection of biomarkers for the diagnosis of tuberculosis by multidimensional GC-MS

    GL Sciences B.V.
    By GL Sciences B.V.

    Tuberculosis (TB) is a global emergency caused by Mycobacterium tuberculosis (MTB). One third of the world population is infected. Finding biomarker(s) for rapid diagnosis of TB becomes one of the essential requirements for TB control. Single biomarkers or combination of a few biomarkers fail in identification of MTB. Recently we have developed a fully automated GC-MS method using Thermally assisted Hydrolysis and Methylation (THM) for sputum analysis from TB-suspected
    patients [1]. In addition, using chemometrics, we found a list of 20 potential compounds giving better accuracy for diagnosis of TB. Unfortunately, the method still needs further improvement because of the adverse effect of the sputum matrix on the detection limit. Moreover, the diagnosis of TB in HIV positive patients, a high risk group for multidrug resistant TB, remains a problem because their sputum contains fewer mycobacteria than the sputum from HIV negative TB patients.

    Original: http://www.atasgl.com/poster/poster-RIVA-2012-UvA.pdf
    Posted: June 11, 2012, 1:50 pm

    GL Sciences B.V.

    GL Sciences B.V.

    Manufacturer of advanced laboratory sample handling and introduction technology for Gas Chromatography instrumentation.
    Business description

    ATAS GL International B.V. has changed her name into GL Sciences B.V.. We are based in Eindhoven, The Netherlands. Founded in 1990, GL Sciences B.V specializes in development and manufacturing of...